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Review
. 2007 Dec;8(6):337-43.
doi: 10.2174/138920107783018426.

RNAi screening for therapeutic targets in human malignancies

David R Micklem  1 , James B Lorens
Affiliations
Review

RNAi screening for therapeutic targets in human malignancies

David R Micklem et al. Curr Pharm Biotechnol. 2007 Dec.

Abstract

The advent of RNA interference (RNAi) based library screening approaches has sparked a surge in loss-of-function genetic screens. Several recent screens have aimed to identify novel regulators of cancer-related phenotypes. These employ various tumor cell types to model malignant cell functions and use different RNAi effector library approaches to reveal a cache of novel tumor regulators. This review surveys recent RNAi screens conducted in transformed human cells.

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