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Review
. 2008;14(5):454-64.
doi: 10.2174/138161208783597326.

The role of heme oxygenase-1 in T cell-mediated immunity: the all encompassing enzyme

Z W Xia  1 , W W Zhong, J S Meyrowitz, Z L Zhang
Affiliations
Review

The role of heme oxygenase-1 in T cell-mediated immunity: the all encompassing enzyme

Z W Xia et al. Curr Pharm Des. 2008.

Abstract

Heme oxygenase-1 (HO-1) is the rate-limiting enzyme of ferroheme metabolic pathway, which has the functions of anti-oxidation, anti-inflammatory, anti-apoptosis and anti-smooth muscle hyperplasia. Furthermore, HO-1 exerts a protective action in the diseases mediated by effector T lymphocytes such as T helper (Th) 1, Th2 and Th17. In addition, regulatory T cells (Treg) control the activity of CD4+CD25- effector cells in a suppressive manner. Numerous studies indicate that the protective action of HO-1 in diseases is through CD4+CD25+ Treg. This paper will review the current research and understanding of HO-1's role in T cells-mediated immunoregulation.

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