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. 2008 Mar 15;18(6):2109-13.
doi: 10.1016/j.bmcl.2008.01.091. Epub 2008 Jan 30.

Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH)

Amy Timmons  1 , Mark Seierstad, Rich Apodaca, Matt Epperson, Dan Pippel, Sean Brown, Leon Chang, Brian Scott, Michael Webb, Sandra R Chaplan, J Guy Breitenbucher
Affiliations

Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH)

Amy Timmons et al. Bioorg Med Chem Lett. .

Abstract

Efforts to improve the properties of the well studied ketooxazole FAAH inhibitor OL-135 resulted in the discovery of a novel propylpiperidine series of FAAH inhibitors that has a modular design and superior properties to OL-135. The efficacy of one of these compounds was demonstrated in a rat spinal nerve ligation model of neuropathic pain in rats.

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