doi: 10.1016/j.bmcl.2008.01.099.
Epub 2008 Jan 31.
Synthesis and biological evaluation of chalcones as inhibitors of the voltage-gated potassium channel Kv1.3
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- PMID: 18289849
- DOI: 10.1016/j.bmcl.2008.01.099
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Synthesis and biological evaluation of chalcones as inhibitors of the voltage-gated potassium channel Kv1.3
Bioorg Med Chem Lett.
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Abstract
Chalcone derivatives of the natural product khellinone were synthesised and screened for bioactivity against the voltage-gated potassium channel Kv1.3. X-ray crystallography was employed to investigate relationships between the structure and function of a selection of the reported chalcones.
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