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. 2008 Mar 15;18(6):2055-61.
doi: 10.1016/j.bmcl.2008.01.099. Epub 2008 Jan 31.

Synthesis and biological evaluation of chalcones as inhibitors of the voltage-gated potassium channel Kv1.3

Julia Cianci  1 , Jonathan B Baell, Bernard L Flynn, Robert W Gable, Jorgen A Mould, Dharam Paul, Andrew J Harvey
Affiliations

Synthesis and biological evaluation of chalcones as inhibitors of the voltage-gated potassium channel Kv1.3

Julia Cianci et al. Bioorg Med Chem Lett. .

Abstract

Chalcone derivatives of the natural product khellinone were synthesised and screened for bioactivity against the voltage-gated potassium channel Kv1.3. X-ray crystallography was employed to investigate relationships between the structure and function of a selection of the reported chalcones.

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