Alpha-fetoprotein and other tumour-associated antigens for immunotherapy of hepatocellular cancer
- PMID: 18294103
- DOI: 10.1517/14712598.8.3.325
Alpha-fetoprotein and other tumour-associated antigens for immunotherapy of hepatocellular cancer
Abstract
Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer death, with few treatment options for advanced disease.
Objectives: Here, we review the aetiology of HCC and focus on recent data on tumour-associated antigens (TAA) for HCC, their functions and potential use as immunological targets for immune-based therapy for HCC. In addition, we examine some aspects of antigen presentation within the liver.
Results/conclusions: alpha-Fetoprotein (AFP) has been investigated for many years as a TAA, and has been tested in recent clinical trials. More recently, additional TAA have been identified and new therapeutic approaches have been investigated which may be testable clinically in this difficult disease setting.
Similar articles
-
Comparative analysis of various tumor-associated antigen-specific t-cell responses in patients with hepatocellular carcinoma.Hepatology. 2011 Apr;53(4):1206-16. doi: 10.1002/hep.24149. Hepatology. 2011. PMID: 21480325
-
Immunobiology and gene-based immunotherapy of hepatocellular carcinoma.Z Gastroenterol. 2003 Nov;41(11):1101-10. doi: 10.1055/s-2003-44304. Z Gastroenterol. 2003. PMID: 14648380 Review.
-
Cell-mediated immune responses to alpha-fetoprotein and other antigens in hepatocellular carcinoma.Liver Int. 2010 Apr;30(4):521-6. doi: 10.1111/j.1478-3231.2009.02194.x. Epub 2009 Dec 22. Liver Int. 2010. PMID: 20040052 Review.
-
Patient-derived dendritic cells transduced with an a-fetoprotein-encoding adenovirus and co-cultured with autologous cytokine-induced lymphocytes induce a specific and strong immune response against hepatocellular carcinoma cells.Liver Int. 2006 Apr;26(3):369-79. doi: 10.1111/j.1478-3231.2005.01235.x. Liver Int. 2006. PMID: 16584401
-
Alpha fetoprotein is more than a hepatocellular cancer biomarker: from spontaneous immune response in cancer patients to the development of an AFP-based cancer vaccine.Curr Mol Med. 2011 Oct;11(7):564-81. doi: 10.2174/156652411800615162. Curr Mol Med. 2011. PMID: 21707514 Review.
Cited by
-
Co-transfection of dendritic cells with AFP and IL-2 genes enhances the induction of tumor antigen-specific antitumor immunity.Exp Ther Med. 2012 Oct;4(4):655-660. doi: 10.3892/etm.2012.635. Epub 2012 Jul 6. Exp Ther Med. 2012. PMID: 23170121 Free PMC article.
-
Immunotherapy for liver tumors: present status and future prospects.J Biomed Sci. 2009 Mar 6;16(1):30. doi: 10.1186/1423-0127-16-30. J Biomed Sci. 2009. PMID: 19272130 Free PMC article. Review.
-
Influenza virus infection elicits protective antibodies and T cells specific for host cell antigens also expressed as tumor-associated antigens: a new view of cancer immunosurveillance.Cancer Immunol Res. 2014 Mar;2(3):263-73. doi: 10.1158/2326-6066.CIR-13-0125. Epub 2013 Dec 5. Cancer Immunol Res. 2014. PMID: 24778322 Free PMC article.
-
Immunotherapy for gastrointestinal malignancies.Cancer Control. 2013 Jan;20(1):32-42. doi: 10.1177/107327481302000106. Cancer Control. 2013. PMID: 23302905 Free PMC article. Review.
-
Polyunsaturated Fatty Acid-Bound α-Fetoprotein Promotes Immune Suppression by Altering Human Dendritic Cell Metabolism.Cancer Res. 2023 May 2;83(9):1543-1557. doi: 10.1158/0008-5472.CAN-22-3551. Cancer Res. 2023. PMID: 36847613 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
