Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2008 May;145(5):894-901.
doi: 10.1016/j.ajo.2007.12.025. Epub 2008 Feb 21.

Retinal thickness on Stratus optical coherence tomography in people with diabetes and minimal or no diabetic retinopathy

Neil M Bressler  1 , Allison R Edwards, Andrew N Antoszyk, Roy W Beck, David J Browning, Antonio P Ciardella, Ronald P Danis, Michael J Elman, Scott M Friedman, Adam R Glassman, Jeffrey G Gross, Helen K Li, Timothy J Murtha, Thomas W Stone, Jennifer K Sun; Diabetic Retinopathy Clinical Research Network
Collaborators, Affiliations
Comparative Study

Retinal thickness on Stratus optical coherence tomography in people with diabetes and minimal or no diabetic retinopathy

Neil M Bressler et al. Am J Ophthalmol. 2008 May.

Abstract

Purpose: To evaluate optical coherence tomography (OCT) thickness of the macula in people with diabetes but minimal or no retinopathy and to compare these findings with published normative data in the literature from subjects reported to have no retinal disease.

Design: Cross-sectional study.

Methods: In a multicenter community- and university-based practices setting, 97 subjects with diabetes with no or minimal diabetic retinopathy and no central retinal thickening on clinical examination and a center point thickness of 225 microm or less on OCT (Stratus OCT; Carl Zeiss Meditec, Dublin, California, USA) were recruited. Electronic Early Treatment of Diabetic Retinopathy Study best-corrected visual acuity, seven-field stereoscopic color fundus photographs, and Stratus OCT fast macular scan were noted. Main outcome measures were central subfield (CSF) thickness measured on Stratus OCT.

Results: On average, CSF thickness was 201 +/- 22 microm. CSF thickness was significantly greater in retinas from men than retinas from women (mean +/- standard deviation, 209 +/- 18 microm vs 194 +/- 23 microm; P < .001). After adjusting for gender, no additional factors were found to be associated significantly with CSF thickness (P > .10).

Conclusions: CSF thicknesses on Stratus OCT in people with diabetes and minimal or no retinopathy are similar to thicknesses reported from a normative database of people without diabetes. CSF thickness is greater in men than in women, consistent with many, but not all, previous reports. Studies involving comparisons of retinal thickness with expected norms should consider different mean values for women and men.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Distribution of Stratus OCT™ retinal thickness in diabetic subjects with minimal or no retinopathy: Mean ± SD (Minimum, Maximum)
Figure 2
Figure 2
Shift in distribution of the mean central subfield thickness by gender in diabetic subjects with minimal or no retinopathy
See this image and copyright information in PMC

References

    1. Chan A, Duker JS. A standardized method for reporting changes in macular thickening using optical coherence tomography. Arch Ophthalmol. 2005;123:939–943. - PubMed
    1. Hee M, Puliafito C, Duker J, et al. Topography of diabetic macualr edema with optical coherence tomography. Ophthalmology. 1998;105:360–370. - PMC - PubMed
    1. Massin P, Erginay A, Haouchine B, Mehidi AB, Paques M, Gaudric A. Retinal thickness in healthy and diabetic subjects measured using optical coherence tomography mapping software. Eur J Ophthalmol. 2002;12:102–128. - PubMed
    1. Goebel W, Kretzchmar-Gross T. Retinal thickness in diabetic retinopathy. A study using optical coherence tomography (OCT) Retina. 2002;22:759–767. - PubMed
    1. Laursen ML, Moeller F, Sander B, Sjoelie AK. Subthreshold micropulse diode laser treatment in diabetic macular edema. Br J Ophthalmol. 2004;88:1173–1179. - PMC - PubMed

Publication types