Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2008 Aug;32(8):1173-5.
doi: 10.1016/j.leukres.2008.01.009. Epub 2008 Feb 21.

Do polymorphisms in ABC transporter genes influence risk of childhood acute lymphoblastic leukemia?

Krzysztof Jamroziak  1 , Tadeusz Robak
Affiliations
Comment

Do polymorphisms in ABC transporter genes influence risk of childhood acute lymphoblastic leukemia?

Krzysztof Jamroziak et al. Leuk Res. 2008 Aug.

Abstract

It is widely accepted that pathogenesis of childhood acute lymphoblastic leukemia (ALL) is related to the interplay between specific environmental exposure and inherited background. Major role of some members of the ATP-binding cassette (ABC) family of membrane transporters including MDR1 (ABCB1, P-glycoprotein) and breast cancer resistant protein (BCRP, ABCG2) is protection against environmental toxins. Here, we review several recent reports on potential association between single nucleotide polymorphisms (SNPs) in genes encoding for ABC transporters with predisposition to pediatric ALL.

PubMed Disclaimer

Comment on

MeSH terms

Substances

LinkOut - more resources