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Review
. 2008 Feb 22;132(4):681-96.
doi: 10.1016/j.cell.2008.01.036.

Stems cells and the pathways to aging and cancer

Derrick J Rossi  1 , Catriona H M Jamieson, Irving L Weissman
Affiliations
Free article
Review

Stems cells and the pathways to aging and cancer

Derrick J Rossi et al. Cell. .
Free article

Abstract

The aging of tissue-specific stem cell and progenitor cell compartments is believed to be central to the decline of tissue and organ integrity and function in the elderly. Here, we examine evidence linking stem cell dysfunction to the pathophysiological conditions accompanying aging, focusing on the mechanisms underlying stem cell decline and their contribution to disease pathogenesis.

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