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Randomized Controlled Trial
. 2008 May;24(5):545-7.
doi: 10.1007/s00381-007-0571-7. Epub 2008 Feb 23.

A dose-response relationship research on botulinum toxin type A local intramuscular injections of lower extremity spasticity in children with cerebral palsy

Yajie Wang  1 , Baoqin Gao
Affiliations
Randomized Controlled Trial

A dose-response relationship research on botulinum toxin type A local intramuscular injections of lower extremity spasticity in children with cerebral palsy

Yajie Wang et al. Childs Nerv Syst. 2008 May.

Abstract

Objectives: To observe the dose-response relationship of intramuscular injections of botulinum toxin A (BTX-A) in the spastic cerebral palsy.

Methods: One hundred fifty cases (age between 2 and 12 years) were randomly divided into three groups. The patients were injected with different dose of BTX-A. The movement function was evaluated with modified Ashworth scale (MAS) and physician's rating scale (PRS) at entry and 1 month after injection. The analyses were conducted with one-way analysis of variance and chi (2) test.

Results: The evaluation of MAS and PRS revealed a significant increase of movement function. No statistically significant differences of the side effects among three groups could be demonstrated.

Conclusions: The study suggested that the movement function was more significantly improved with relatively higher dose of BTX-A, which was safe and effective.

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