Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Mar 18;47(11):3317-21.
doi: 10.1021/bi800049z. Epub 2008 Feb 26.

Free-energy landscape of enzyme catalysis

Stephen J Benkovic  1 , Gordon G Hammes, Sharon Hammes-Schiffer
Affiliations
Review

Free-energy landscape of enzyme catalysis

Stephen J Benkovic et al. Biochemistry. .

Abstract

The concept is developed that enzyme mechanisms should be viewed as "catalytic networks" with multiple conformations that occur serially and in parallel in the mechanism. These coupled ensembles of conformations require a multi-dimensional standard free-energy surface that is very "rugged", containing multiple minima and transition states. Experimental and theoretical evidence is presented to support this concept.

PubMed Disclaimer

Publication types

MeSH terms

Substances