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Review
. 2008 Mar;24(1):87-104.
doi: 10.1016/j.cvfa.2007.11.001.

Neonatal immune development in the calf and its impact on vaccine response

Christopher C L Chase  1 , David J Hurley, Adrian J Reber
Affiliations
Review

Neonatal immune development in the calf and its impact on vaccine response

Christopher C L Chase et al. Vet Clin North Am Food Anim Pract. 2008 Mar.

Abstract

In this article we cover the immunologic response as it develops, the components of passive immunity, and the immune response of young calves. We discuss interference from maternal immunity in the development of specific immunity and vaccine strategies for developing protection against pathogens in calves.

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Figures

Fig. 1
Fig. 1
Development of the immune response in the calf: from conception to puberty. (Data from Morein B, Abusugra I, Blomqvist G. Immunity in neonates. Vet Immunol Immunopath 2002;87:207–13; and Butler JE, Sinkora M, Wertz N, et al. Development of the neonatal B and T cell repertoire in swine: implications for comparative and veterinary immunology. Vet Res 2006;37:419.)
Fig. 2
Fig. 2
Immunosuppression of the neonatal calf. (Adapted from Morein B, Abusugra I, Blomqvist G. Immunity in neonates. Vet Immunol Immunopath 2002;87:207–13; with permission. Calf clipart from www.clipartheaven.com.)
Fig. 3
Fig. 3
Importance of vaccine timing and the booster response. (Courtesy of D. Topham, PhD, Rochester, NY.)
See this image and copyright information in PMC

References

    1. Barrington G.M. Bovine neonatal immunology. Vet Clin North Am Food Anim Pract. 2001;17:463–476. - PMC - PubMed
    1. Charleston B., Fray M.D., Baigent S. Establishment of persistent infection with non-cytopathic bovine viral diarrhoea virus in cattle is associated with a failure to induce type I interferon. J Gen Virol. 2001;82:1893–1897. - PubMed
    1. Wilson R.A., Zonai A., Rudas P. T-cell subsets in blood and lymphoid tissues obtained from fetal calves, maturing calves, and adult bovine. Vet Immunol Immunopathol. 1996;53:49–60. - PubMed
    1. Kampen A.H., Olsen I., Tollersrud T. Lymphocyte subpopulations and neutrophil function in calves during the first 6 months of life. Vet Immunol Immunopathol. 2006;113:53–63. - PubMed
    1. Senogles D.R., Paul P.S., Johnson D.W. Ontogeny of T cells, B cells and monocytes in the bovine foetus. Clin Exp Immunol. 1979;36:299–303. - PMC - PubMed