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Comment
. 2008 Mar 4;105(9):3177-8.
doi: 10.1073/pnas.0800667105. Epub 2008 Feb 25.

Chance favors a prepared genome

Jonathan P Stoye  1 , Melvyn W Yap
Affiliations
Comment

Chance favors a prepared genome

Jonathan P Stoye et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Genomic organization and sequence of Trim5CypA2. (A) Organization of Trim5 gene showing the CypA insertions in Trim5CypA1 and Trim5CypA2. Coding exons (solid lines) and noncoding exons (dashed lines) are drawn to scale. Exon numbers are found at the top, and the mRNA derived from splicing are indicated below. The Trim5 domains (RING, B-Box, CC, B30.2, and CypA) are color-coded. Splice donors and acceptors are depicted as circles at the bottom of the boxes representing the exons. CypA is inserted between exons 7 and 8 in Trim5CypA1, where exon 7 is spliced to CypA instead of exon 8. In Trim5CypA2, CypA is inserted within the noncoding part of exon 8, and inactivation of the splice acceptor site in exon7 results in the splicing of exon 6 to CypA. (B) Sequence of the CypA insertion in Trim5CypA2. The inserted sequence, which is highlighted in green, is flanked by target site duplications, which are highlighted in yellow. The CypA reading frame is colored orange. The splice acceptor site (orange arrowhead), HIV-2 specificity determinant (cyan hexagon), and polyadenylation signals (red bar) are indicated.
See this image and copyright information in PMC

Comment on

References

    1. Bieniasz PD. Nat Immunol. 2004;5:1109–1115. - PubMed
    1. Stremlau M, Owens CM, Perron MJ, Kiessling M, Autissier P, Sodroski J. Nature. 2004;427:848–853. - PubMed
    1. Wu X, Anderson JL, Campbell EM, Joseph AM, Hope TJ. Proc Natl Acad Sci USA. 2006;103:7465–7470. - PMC - PubMed
    1. Meroni G, Diez-Roux G. BioEssays. 2005;27:1147–1157. - PubMed
    1. Sayah DM, Sokolskaja E, Berthoux L, Luban J. Nature. 2004;340:569–573. - PubMed

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