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. 2008;47(14):2677-80.
doi: 10.1002/anie.200705589.

Exploring the differential recognition of DNA G-quadruplex targets by small molecules using dynamic combinatorial chemistry

Anthony Bugaut  1 , Katja Jantos, Jean-Luc Wietor, Raphaël Rodriguez, Jeremy K M Sanders, Shankar Balasubramanian
Affiliations

Exploring the differential recognition of DNA G-quadruplex targets by small molecules using dynamic combinatorial chemistry

Anthony Bugaut et al. Angew Chem Int Ed Engl. 2008.
No abstract available

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Figures

Figure 1
Figure 1
Expansions of the HPLC traces of templated and untemplated a) DCL1 and b) DCL2, and proportion changes of macrocycle-side-chain conjugates in c) DCL1 and d) DCL2 upon introduction of c-Kit21.
Figure 2
Figure 2
Proportion changes of the macrocycle-side-chain conjugates in DCL1 upon introduction of c-Myc22.
Figure 3
Figure 3
Proportion changes of the macrocycle-side-chain conjugates in DCL2 upon introduction of c-Myc22.
Scheme 1
Scheme 1
a) Structure of the oxazole-based peptide macrocycle 1. b) Structures of side chains that are cationic (A-E, library L1) and neutral (carbohydrate derivatives F-I, library L2) at physiological pH value.
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