doi: 10.1128/JVI.19.2.291-295.1976.
Induction of DNA polymerase in polyoma virus-infected mouse cells requires transcription and translation
- PMID: 183005
- PMCID: PMC354864
- DOI: 10.1128/JVI.19.2.291-295.1976
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Induction of DNA polymerase in polyoma virus-infected mouse cells requires transcription and translation
J Virol.
1976 Aug.
Abstract
The induction of DNA polymerase activity and of DNA synthesis in polyoma virus-infected mouse kidney cells is inhibited by actinomycin D and cycloheximide, even in cells that are already T-antigen positive. This indicates that the induction of the DNA-synthesizing apparatus requires transcription and translation. The increase in cellular DNA polymerase activity and in the DNA synthesizing capacity follows the appearance of T-antigen only after a characteristic lag period of several hours.
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