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. 1976 Aug;19(2):331-7.
doi: 10.1128/JVI.19.2.331-337.1976.

Size of murine RNA tumor virus-specific nuclear RNA molecules

W A Haseltine, D Baltimore

Size of murine RNA tumor virus-specific nuclear RNA molecules

W A Haseltine et al. J Virol. 1976 Aug.

Abstract

About 1% of the total RNA of cell lines producing murine leukemia virus is virus-specific RNA. About one-third of the virus-specific RNA is located within the nucleus. The size distribution of virus-specific RNA was determined before and after denaturation. Before denaturation, virus-specific RNA sequences sedimented as a heterogeneous population of RNA molecules, some of which sedimented very rapidly. After denaturation, most of the virus-specific RNA had a sedimentation coefficient of 35S or lower, but a small fraction of the nuclear virus-specific RNA sedimented more rapidly than 35S RNA even after denaturation.

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