doi: 10.1016/0006-8993(91)91171-v.
Chronic effects of gamma-interferon on quinolinic acid and indoleamine-2,3-dioxygenase in brain of C57BL6 mice
Affiliations
- PMID: 1830237
- DOI: 10.1016/0006-8993(91)91171-v
Item in Clipboard
Chronic effects of gamma-interferon on quinolinic acid and indoleamine-2,3-dioxygenase in brain of C57BL6 mice
Brain Res.
.
Abstract
Chronic infections are associated with increased concentrations of the neuroactive kynurenine pathway metabolite, quinolinic acid (QUIN), in blood and cerebrospinal fluid. In the present study, repeated injections of gamma-interferon (5000 IU, every 3 days for 39 days) to C57BL6 mice were associated with persistent activation of indoleamine-2,3-dioxygenase (IDO), the first enzyme of the kynurenine pathway, in lung and brain, sustained increases in brain QUIN concentration and increases in plasma L-kynurenine and QUIN levels. Mice chronically treated with gamma-interferon offer an animal model to investigate the effects of sustained immune stimulation on kynurenine pathway metabolism.
Similar articles
-
Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse.Neuroscience. 1992 Nov;51(1):25-39. doi: 10.1016/0306-4522(92)90467-g. Neuroscience. 1992. PMID: 1465184
-
A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.Brain. 1993 Dec;116 ( Pt 6):1425-50. doi: 10.1093/brain/116.6.1425. Brain. 1993. PMID: 8293279
-
Poliovirus induces indoleamine-2,3-dioxygenase and quinolinic acid synthesis in macaque brain.FASEB J. 1992 Aug;6(11):2977-89. doi: 10.1096/fasebj.6.11.1322853. FASEB J. 1992. PMID: 1322853
-
Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway.Int J Biochem Cell Biol. 2009 Mar;41(3):467-71. doi: 10.1016/j.biocel.2008.01.005. Epub 2008 Jan 11. Int J Biochem Cell Biol. 2009. PMID: 18282734 Review.
-
Network beyond IDO in psychiatric disorders: revisiting neurodegeneration hypothesis.Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jan 3;48:304-13. doi: 10.1016/j.pnpbp.2013.08.008. Epub 2013 Oct 31. Prog Neuropsychopharmacol Biol Psychiatry. 2014. PMID: 24184687 Review.
Cited by
-
Induction of pterin synthesis is not required for cytokine-stimulated tryptophan metabolism.Biochem J. 1993 Oct 15;295 ( Pt 2)(Pt 2):543-7. doi: 10.1042/bj2950543. Biochem J. 1993. PMID: 8240255 Free PMC article.
-
Decreased protein nitration in macrophages that overexpress indoleamine 2, 3-dioxygenase.Cell Mol Biol Lett. 2007;12(1):82-102. doi: 10.2478/s11658-006-0048-9. Epub 2006 Nov 13. Cell Mol Biol Lett. 2007. PMID: 17103092 Free PMC article.
-
The possible association between Toxoplasma gondii infection and risk of anxiety and cognitive disorders in BALB/c mice.Pathog Glob Health. 2015;109(8):369-76. doi: 10.1080/20477724.2015.1117742. Pathog Glob Health. 2015. PMID: 26924347 Free PMC article.
-
4-Chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-gamma-stimulated monocytes (THP-1 cells).Biochem J. 1993 Apr 1;291 ( Pt 1)(Pt 1):11-4. doi: 10.1042/bj2910011. Biochem J. 1993. PMID: 8471029 Free PMC article.
-
Toxoplasma gondii Infection Promotes Neuroinflammation Through Cytokine Networks and Induced Hyperalgesia in BALB/c Mice.Inflammation. 2016 Feb;39(1):405-412. doi: 10.1007/s10753-015-0262-6. Inflammation. 2016. PMID: 26490968
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
