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Case Reports
. 2007 Oct-Dec;51(4):9-11.

[Osteoporosis: diagnosis or sign of suspicion?]

[Article in Spanish]
M D Lorente  1 , C Marginet, P Pujante
Affiliations
  • PMID: 18303656
Free article
Case Reports

[Osteoporosis: diagnosis or sign of suspicion?]

[Article in Spanish]
M D Lorente et al. Rev Med Univ Navarra. 2007 Oct-Dec.
Free article

Abstract

Purpose: We present the case of a fifty-year-old male who presented at the Neurology Service. During the previous months he had noticed progressive cognitive deterioration, and particularly a loss of memory and executive abilities, as well as proximal weakness of the four limbs and lumbar tenderness. He had lost ten centimetres of height. A bone densitometry was performed, which showed early osteoporosis.

Results/conclusions: The laboratory results showed an increase in urine cortisol excretion (1725 g/24h), with detectable plasma ACTH concentration (89 pg/ml), suggesting ACTH-dependent Cushing's syndrome, Additional tests were run in order to determine a hypothalamic or ectopic location of the syndrome. To this end, a bilateral inferior petrosal sinus sample (BIPSS) was performed for ACTH determination. BIPSS is the test that has been proven to have the best sensitivity to achieve differential diagnosis of ACTH-dependent Cushing's syndrome.

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