14-3-3 proteins regulate the potassium channel KAT1 by dual modes
- PMID: 18304197
- DOI: 10.1111/j.1438-8677.2007.00028.x
14-3-3 proteins regulate the potassium channel KAT1 by dual modes
Abstract
KAT1 is a cloned plant potassium channel belonging to the superfamily of Shaker-like Kv channels. Previous studies have shown that 14-3-3 proteins significantly increase KAT1 current by modifying the channel open probability. Employing a 14-3-3 scavenger construct to lower the long-term availability of endogenous 14-3-3 proteins, we found that 14-3-3 proteins not only control the voltage dependency of the channel but also the number of channels in the plasma membrane.
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