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Review
. 2008 Feb 28;57(4):477-9.
doi: 10.1016/j.neuron.2008.02.004.

Ama "zinc" link between TrkB transactivation and synaptic plasticity

Guhan Nagappan  1 , Newton H Woo, Bai Lu
Affiliations
Free article
Review

Ama "zinc" link between TrkB transactivation and synaptic plasticity

Guhan Nagappan et al. Neuron. .
Free article

Abstract

While Trk receptors can be activated in a neurotrophin-independent manner through "transactivation" by GPCR ligands, its physiological significance in the brain remains unknown. Huang et al. have now identified a novel mechanism of TrkB transactivation. They show that zinc ions can transactivate TrkB independent of neurotrophins and that such a transactivation is important for mossy fiber long-term potentiation (LTP).

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