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. 2008 Mar 15;18(6):1804-9.
doi: 10.1016/j.bmcl.2008.02.024. Epub 2008 Feb 14.

Phenylethynyl-pyrrolo[1,2-a]pyrazine: a new potent and selective tool in the mGluR5 antagonists arena

Fabrizio Micheli  1 , Barbara Bertani, Andrea Bozzoli, Luca Crippa, Paolo Cavanni, Romano Di Fabio, Daniele Donati, Paola Marzorati, Giancarlo Merlo, Alfredo Paio, Lorenzo Perugini, Paola Zarantonello
Affiliations

Phenylethynyl-pyrrolo[1,2-a]pyrazine: a new potent and selective tool in the mGluR5 antagonists arena

Fabrizio Micheli et al. Bioorg Med Chem Lett. .

Abstract

The synthesis and the structure activity of a new series of pyrrolo[1,2-a]pyrazine is reported. These molecules are potent and selective non-competitive mGluR5 antagonists and may shed new light on the pattern of substitution tolerated by this receptor.

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