Review
doi: 10.1016/j.cyto.2008.01.006.
Epub 2008 Mar 4.
LPS/TLR4 signal transduction pathway
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- PMID: 18304834
- DOI: 10.1016/j.cyto.2008.01.006
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Review
LPS/TLR4 signal transduction pathway
Cytokine.
2008 May.
Abstract
The stimulation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) induces the release of critical proinflammatory cytokines that are necessary to activate potent immune responses. LPS/TLR4 signaling has been intensively studied in the past few years. Here we review molecules involved in TLR4-mediated signaling, including players that are involved in the negative regulation of this important pathway.
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