Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 May;42(2):145-151.
doi: 10.1016/j.cyto.2008.01.006. Epub 2008 Mar 4.

LPS/TLR4 signal transduction pathway

Yong-Chen Lu  1 , Wen-Chen Yeh  2 , Pamela S Ohashi  3
Affiliations
Review

LPS/TLR4 signal transduction pathway

Yong-Chen Lu et al. Cytokine. 2008 May.

Abstract

The stimulation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) induces the release of critical proinflammatory cytokines that are necessary to activate potent immune responses. LPS/TLR4 signaling has been intensively studied in the past few years. Here we review molecules involved in TLR4-mediated signaling, including players that are involved in the negative regulation of this important pathway.

PubMed Disclaimer

LinkOut - more resources