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. 2008 Winter;20(1):101-5.
doi: 10.1176/jnp.2008.20.1.101.

Restless legs syndrome is associated with DSM-IV major depressive disorder and panic disorder in the community

Hochang B Lee  1 , Wayne A Hening, Richard P Allen, Amanda E Kalaydjian, Christopher J Earley, William W Eaton, Constantine G Lyketsos
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Restless legs syndrome is associated with DSM-IV major depressive disorder and panic disorder in the community

Hochang B Lee et al. J Neuropsychiatry Clin Neurosci. 2008 Winter.

Abstract

The authors examined the association between restless legs syndrome (RLS) and DSM-IV major depressive disorder and panic disorder based on Wave III and IV of the Baltimore ECA follow-up study. Of 1071 participants, 1024 completed the RLS Questionnaire and Diagnostic Interview Schedule. Adjusted odds ratio for diagnosis of major depressive disorder (4.7, 95% confidence interval [1.6, 14.5]) and panic disorder (12.9 [3.6, 46.0]) and comorbidity of major depressive disorder and panic disorder (9.7 [1.4, 69.0]) in the past 12 months suggested a strong association between restless legs syndrome and major depressive disorder and/or panic disorder.

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