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. 2008 Feb 5;13(2):255-66.
doi: 10.3390/molecules13020255.

New benzoyl glucosides and cytotoxic pterosin sesquiterpenes from Pteris ensiformis Burm

Yung-Husan Chen  1 , Fang-Rong Chang, Mei-Chin Lu, Pei-Wen Hsieh, Ming-Jiuan Wu, Ying-Chi Du, Yang-Chang Wu
Affiliations

New benzoyl glucosides and cytotoxic pterosin sesquiterpenes from Pteris ensiformis Burm

Yung-Husan Chen et al. Molecules. .

Abstract

Three new compounds: 2R,3R-pterosin L 3-O-beta-D-glucopyranoside (1), beta-D-xylopyranosyl(1-->2)-7-O-benzoyl-beta-D-glucopyranoside (2) and 4-O-benzoyl-beta-D-xylo-pyranosyl(1-->2)-7-O-benzoyl-beta-D-glucopyranoside (3), together with nine known compounds, were isolated from the ethyl acetate extract of Pteris ensiformis. 5-[2-Hydroxyethylidene]-2(5H)-furanone (4), which had been synthesized, was isolated from natural sources for the first time. The structures of all isolated compounds were determined on the basis of mass and spectroscopic evidence. Compound 1 and pterosin B (5) show cytotoxicity against HL 60 cells (human leukemia) with the IC(50) values of 3.7 and 8.7 microg/mL, respectively.

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Figures

Figure 1
Figure 1
Structures of compounds 1-10.
Figure 2
Figure 2
NOESY and HMBC correlations of compound 1.
Figure 3
Figure 3
COSY and HMBC correlations of compound 4.
See this image and copyright information in PMC

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References

    1. Wu M.J., Wang L., Weng C.Y., Lian T.W. Immunomodulatory mechanism of the aqueous extract of sword brake fern (Pteris ensiformis Burm.) J. Ethnopharmacol. 2005;98:73–81. doi: 10.1016/j.jep.2004.12.031. - DOI - PubMed
    1. Gong X.L., Chen Z.H., Liang N.C. Advances in study on chemical constituents and pharmacological activities of plants of genus Pteris. Zhongguo Zhong Yao Za Zhi. 2007;32:1382–1387. - PubMed
    1. Castillo U.F., Ojika M., Alonso-Amelot M., Sakagamia Y., Ptaquiloside Z. a new toxic unstable sesquiterpene glucoside from the neotropical bracken fern Pteridium Aquilinum Var. Caudatum. Bioorg. Med. Chem. 1998;6:2229–2233. doi: 10.1016/S0968-0896(98)00168-0. - DOI - PubMed
    1. Jesudass L.L., Manickam V.S., Gopalakrishnan S. Polyphenolic glycosides of Pteris confusa T.G. walker of kothayar hills of the western ghats of south India. Res. J. Chem. Environ. 2000;4:77–78.
    1. Salatino M.L., Prado F. Flavonoid glycosides of Pteridaceae from Brazil. J. Bio. System. Eco. 1998;26:761–769. doi: 10.1016/S0305-1978(98)00032-5. - DOI

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