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Review
. 2008 Feb 6;13(2):272-300.
doi: 10.3390/molecules13020272.

Progress in the studies on rutaecarpine

Seung Ho Lee  1 , Jong-Keun Son, Byeong Seon Jeong, Tae-Cheon Jeong, Hyeon Wook Chang, Eung-Seok Lee, Yurngdong Jahng
Affiliations
Review

Progress in the studies on rutaecarpine

Seung Ho Lee et al. Molecules. .

Abstract

Rutaecarpine is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs, which has shown a variety of intriguing biological properties such as anti-thrombotic, anticancer, anti-inflammatory and analgesic, anti-obesity and thermoregulatory, vasorelaxing activity, as well as effects on the cardiovascular and endocrine systems. Recent progress in the studies on the isolation, synthesis, structure-activity relationship studies, biological activities and metabolism of rutaecarpine are reviewed.

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Figures

Figure 1
Figure 1
Structure and two forms of rutaecarpine molecules with numbering [9].
Scheme 1
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Figure 2
Figure 2
Metabolites of rutaecarpine.
Figure 3
Figure 3
In vivo Phase II metabolites of rutaecarpine.
See this image and copyright information in PMC

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