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Case Reports
. 2008;18(2):208-11.
doi: 10.1007/s10165-008-0034-3. Epub 2008 Feb 29.

Tacrolimus-induced lung injury in a rheumatoid arthritis patient with interstitial pneumonitis

Yusuke Miwa  1 , Takeo Isozaki, Kuninobu Wakabayashi, Tsuyoshi Odai, Mizuho Matsunawa, Nobuyuki Yajima, Masao Negishi, Hirotsugu Ide, Tsuyoshi Kasama, Mitsuru Adachi, Tomoyuki Hisayuki, Tamiko Takemura
Affiliations
Case Reports

Tacrolimus-induced lung injury in a rheumatoid arthritis patient with interstitial pneumonitis

Yusuke Miwa et al. Mod Rheumatol. 2008.

Abstract

A 74-year-old woman was experiencing rheumatoid arthritis complicated with interstitial pneumonitis (IP), and tacrolimus treatment was started. She presented with dyspnea. Chest X-ray and computed tomography (CT) showed ground-glass opacity and IP. Although tacrolimus was stopped, she died of respiratory failure. At autopsy, both the upper and lower lung fields showed usual IP and the organizing stage of diffuse alveolar damage. The former is common, but the latter is uncommon, suggesting tacrolimus may cause severe alveolar damage.

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