doi: 10.1016/j.bmcl.2008.02.029.
Epub 2008 Feb 16.
Indole- and indolizine-glyoxylamides displaying cytotoxicity against multidrug resistant cancer cell lines
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- PMID: 18308566
- DOI: 10.1016/j.bmcl.2008.02.029
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Indole- and indolizine-glyoxylamides displaying cytotoxicity against multidrug resistant cancer cell lines
Bioorg Med Chem Lett.
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Abstract
We report herein the SAR studies of a series of indole- and indolizine-glyoxylamides that demonstrate substantial in vitro anti-proliferative activities against cancer cell lines, including multidrug resistance (MDR) phenotypes. The in vitro cytotoxic effects have been demonstrated across a wide array of tumor types of various origins (e.g., breast, colon, uterine).
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