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. 1991 Jul;87(3):367-8.
doi: 10.1007/BF00200921.

Human platelet basic protein/connective tissue activating peptide-III maps in a gene cluster on chromosome 4q12-q13 along with other genes of the beta-thromboglobulin superfamily

R H Wenger  1 , H Hameister, K J Clemetson
Affiliations

Human platelet basic protein/connective tissue activating peptide-III maps in a gene cluster on chromosome 4q12-q13 along with other genes of the beta-thromboglobulin superfamily

R H Wenger et al. Hum Genet. 1991 Jul.

Abstract

Pro-platelet basic protein (pro-PBP) is the precursor of the two platelet alpha-granule proteins, PBP and connective tissue activating peptide-III. Upon platelet activations they are released and further processed in plasma to beta-thromboglobulin and neutrophil-activating peptide-2. The gene encoding pro-PBP is mapped in this study to chromosome 4q12-q13. At least four other members of this family of small inducible cytokines, including NAP-1/Il-8 and platelet factor 4, reside within the same locus, indicating a gene cluster for the beta-thromboglobulin family.

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