Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2008 Mar;5(3):225-6.
doi: 10.1038/nmeth0308-225.

Harnessing mismatch repair to model sporadic cancers

Richard Fishel  1 , Joanna Groden
Affiliations
Comment

Harnessing mismatch repair to model sporadic cancers

Richard Fishel et al. Nat Methods. 2008 Mar.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Two mouse models designed to recapitulate the initial sporadic mutation step(s) of tumorigenesis. (a) Akyol et al. constructed a transgenic mouse containing ~80 copies of a 22GCre driven by a tissue-specific promoter. (b) Miller et al. targeted the mouse Pms2 gene by replacing exon2 with a frameshift 12ACre. In both models, sporadic frameshift reversion to 21GCre or 11ACre result in mosaic activation of the Cre recombinase, which in turn may act on oncogene or tumor suppressor genes containing proximal loxP sites. IRES, internal ribosome entry site.
See this image and copyright information in PMC

Comment on

References

    1. Nowell PC. Science. 1976;194:23–28. - PubMed
    1. Hanahan D, Weinberg RA. Cell. 2000;100:57–70. - PubMed
    1. O’Brien T, Woychik R. Nat Genet. 2003;33:3–4. - PubMed
    1. Akyol A, et al. Nat Methods. 2008;5:231–233. - PMC - PubMed
    1. Miller AJ, Dudley SD, Tsao JL, Shibata D, Liskay RM. Nat Methods. 2008;5:227–229. - PMC - PubMed