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. 2008 Mar;16(3):194-200.
doi: 10.1097/JGP.0b013e318157c5b1.

Medical burden in late-life bipolar and major depressive disorders

Ariel G Gildengers  1 , Ellen M Whyte, Rebecca A Drayer, Isabella Soreca, Andrea Fagiolini, Amy M Kilbourne, Patricia R Houck, Charles F Reynolds 3rd, Ellen Frank, David J Kupfer, Benoit H Mulsant
Affiliations

Medical burden in late-life bipolar and major depressive disorders

Ariel G Gildengers et al. Am J Geriatr Psychiatry. 2008 Mar.

Abstract

Background: Elderly patients with bipolar disorder have been found to have higher mortality than those with major depressive disorder. The authors compare medical burden in elderly patients with bipolar disorder with that in those with major depressive disorder.

Methods: Fifty-four patients with bipolar I or II disorder who were 60 years of age and older were equated 1-to-2 to 108 patients with nonpsychotic, major depressive disorder according to age, sex, race, and lifetime duration of mood disorder illness. Variables examined included the following: Cumulative Illness Rating Scale for Geriatrics (CIRS-G) total scores, body mass index (BMI), and CIRS-G subscale scores.

Results: Compared with patients with major depressive disorder, patients with bipolar disorder had similar levels of general medical comorbidity on the CIRS-G total score and number of systems affected but higher BMI. After controlling for multiple comparisons, the endocrine/metabolic and respiratory subscale scores on the CIRS-G were higher for patients with bipolar disorder.

Conclusion: Although overall medical burden appears comparable in elderly patients with bipolar and those with major depressive disorder, patients with bipolar disorder have higher BMI and greater burden of endocrine/metabolic and respiratory disease.

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Figures

FIGURE 1
FIGURE 1
Comulative Illness Rating Scale: Geriatric Subscale Scores in Subjects with Bipolar Disorder Versus Major Depressive Disorder
See this image and copyright information in PMC

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