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Editorial
. 2008 Mar;192(3):161-3.
doi: 10.1192/bjp.bp.107.037218.

CATIE and CUtLASS: can we handle the truth?

Shôn Lewis, Jeffrey Lieberman
Editorial

CATIE and CUtLASS: can we handle the truth?

Shôn Lewis et al. Br J Psychiatry. 2008 Mar.

Abstract

Two large, non-commercial clinical trials comparing first- and second-generation antipsychotic drugs for people with chronic schizophrenia in the US and UK have shown unexpected results. In general, the newer drugs were no more effective or better tolerated than the older drugs. Clozapine outperformed other second-generation drugs. The implications are considered.

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