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Case Reports
. 2008;47(5):405-10.
doi: 10.2169/internalmedicine.47.0476. Epub 2008 Mar 3.

Familial aggregation in patients with non-alcoholic steatohepatitis

Katsutoshi Tokushige  1 , Satoru Yatsuji, Etsuko Hashimoto, Ayae Kabutake, Maki Tobari, Makiko Taniai, Keiko Shiratori
Affiliations
Free article
Case Reports

Familial aggregation in patients with non-alcoholic steatohepatitis

Katsutoshi Tokushige et al. Intern Med. 2008.
Free article

Abstract

We encountered three families that showed NASH accumulation. In family #1, a 21-year-old son and 10-year-old daughter were diagnosed with nonalcoholic steatohepatitis (NASH). They shared two adiponectin-gene single nucleotide polymorphisms (SNP). In family #2, a 51-year-old mother and 27-year-old son were diagnosed with NASH and shared the SNPs of other genes. In family #3, a 66-year-old mother and 34-year-old son were diagnosed with NASH and shared the SNPs of other genes. SNP sites differed among the three families, suggesting that the genes associated with the occurrence of NASH might be different in each patient.

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