doi: 10.1016/j.molcel.2008.02.005.
A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis
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- PMID: 18313377
- DOI: 10.1016/j.molcel.2008.02.005
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A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis
Mol Cell.
.
Free article
Abstract
DRP1, a member of the dynamin family of large GTPases, mediates mitochondrial fission. In a recent issue of Developmental Cell, Cassidy-Stone et al. (2008) identified mdivi-1, a new DRP1 inhibitor that prevents mitochondria division and Bax-mediated mitochondrial outer membrane permeabilization during apoptosis.
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