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Editorial
. 2008 Mar;5(3):436-7.
doi: 10.1016/j.hrthm.2008.01.014. Epub 2008 Jan 17.

Ion channel mutations in AF: signal or noise?

Patrick T Ellinor, Calum A MacRae
Editorial

Ion channel mutations in AF: signal or noise?

Patrick T Ellinor et al. Heart Rhythm. 2008 Mar.
No abstract available

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Figures

Figure 1
Figure 1. Ion channel mutations are rare in atrial fibrillation
Compilation from the literature of the total number of subjects with AF screened for each gene versus total number of mutations identified in these genes. Note: Only mutations in subjects with AF are illustrated. Some series of patients were selected cases of familial AF. Figure based on references: -, , but it is anticipated that similar studies are underway at other centers. Since not all subjects have been screened for every gene, it is not possible to determine the precise frequency of these mutations.
See this image and copyright information in PMC

Comment in

References

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    1. Calloe K, Ravn LS, Schmitt N, et al. Characterizations of a loss-of-function mutation in the Kir3.4 channel subunit. Biochem Biophys Res Commun. 2007 Dec 28;364(4):889–895. - PubMed
    1. Olson TM, Alekseev AE, Moreau C, et al. KATP channel mutation confers risk for vein of Marshall adrenergic atrial fibrillation. Nat Clin Pract Cardiovasc Med. 2007 Feb;4(2):110–116. - PMC - PubMed
    1. Ellinor PT, Petrov-Kondratov VI, Zakharova E, Nam EG, MacRae CA. Potassium channel gene mutations rarely cause atrial fibrillation. BMC Med Genet. 2006;7:70. - PMC - PubMed
    1. Olson TM, Alekseev AE, Liu XK, et al. Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation. Hum Mol Genet. 2006 Jul 15;15(14):2185–2191. - PubMed

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