Microtubule dynamics regulated by stathmin

Abstract

Microtubules perform a variety of functions which lead to the complex regulation of intracellular transport and cell division. However, the regulation of microtubule growth is not clearly known. Based on a recent experimental finding, we explore the possibility of spatial regulation of microtubule growth by stathmin-tubulin interaction gradients. Computer simulation of the model with stathmin-tubulin interaction gradients gave regulated growth as seen in experiments. In future, the stathmin-tubulin interaction gradients can be made dynamic and its impact on the microtubule growth can be explored.