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. 2008 Mar 12;22(5):653-5.
doi: 10.1097/QAD.0b013e3282f470d2.

Improvement in HIV-related endothelial dysfunction using the anti-inflammatory agent salsalate: a pilot study

Samir K Gupta  1 , Raymond M Johnson, Chandan Saha, Kieren J Mather, Martha L Greenwald, Jeffrey S Waltz, Jalees Rehman, Michael P Dubé
Affiliations

Improvement in HIV-related endothelial dysfunction using the anti-inflammatory agent salsalate: a pilot study

Samir K Gupta et al. AIDS. .

Abstract

We hypothesized that heightened systemic inflammation contributes to the increased rate of cardiovascular events in HIV-infected patients not receiving combination antiretroviral therapy. We performed a pilot trial to assess the effects of the nuclear factor-kappaB inhibitor salsalate on flow-mediated dilation of the brachial artery, a measure of endothelial function. Flow-mediated dilation significantly improved after 8 weeks of salsalate. However, hepatotoxicity occurred frequently. Research using alternative agents is warranted to examine the role of inflammation in HIV-related cardiovascular disease.

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