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. 1991 Aug 19;288(1-2):13-6.
doi: 10.1016/0014-5793(91)80991-b.

Adipogenesis inhibitory factor. A novel inhibitory regulator of adipose conversion in bone marrow

J Ohsumi  1 , K Miyadai, I Kawashima, H Ishikawa-Ohsumi, S Sakakibara, K Mita-Honjo, Y Takiguchi
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Free article

Adipogenesis inhibitory factor. A novel inhibitory regulator of adipose conversion in bone marrow

J Ohsumi et al. FEBS Lett. .
Free article

Abstract

Recombinant adipogenesis inhibitory factor (AGIF) was purified to homogeneity from the conditioned medium of COS-1 cells transfected with human AGIF cDNA. The amino-terminal sequence analysis of the mature AGIF revealed that AGIF was produced as a precursor consisting of 199 amino acids and processed into a mature form of 178 amino acids by a cleavage between Ala(-1) and Pro(+1). The purified AGIF inhibited the process of adipogenesis in mouse 3T3-L1 preadipocytes, indicating that AGIF directly acts on the cells. AGIF acted as an adipogenic antagonist not only on the extramedullary cell line 3T3-L1 but also on the mouse bone marrow stroma-derived cell line H-1/A, suggesting that this cytokine may regulate adipogenesis in bone marrow.

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