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. 2008 Mar 26;130(12):3728-9.
doi: 10.1021/ja074003o. Epub 2008 Mar 6.

Direct asymmetric iodination of aldehydes using an axially chiral bifunctional amino alcohol catalyst

Taichi Kano  1 , Mitsuhiro Ueda, Keiji Maruoka
Affiliations

Direct asymmetric iodination of aldehydes using an axially chiral bifunctional amino alcohol catalyst

Taichi Kano et al. J Am Chem Soc. .

Abstract

A direct asymmetric iodination reaction of aldehydes with NIS was found to be catalyzed by the novel axially chiral bifunctional amino alcohol (S)-1d. This method represents the rare example of the catalytic and highly enantioselective synthesis of optically active alpha-iodoaldehydes.

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