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. 2008 Apr 15;16(8):4516-22.
doi: 10.1016/j.bmc.2008.02.055. Epub 2008 Feb 21.

Antifungal and antimycobacterial activity of 1-(3,5-diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives

Daniele Zampieri  1 , Maria Grazia Mamolo, Erik Laurini, Giuditta Scialino, Elena Banfi, Luciano Vio
Affiliations

Antifungal and antimycobacterial activity of 1-(3,5-diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives

Daniele Zampieri et al. Bioorg Med Chem. .

Abstract

1-(3,5-Diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives were synthesized and tested for their in vitro antifungal and antimycobacterial activities. These imidazole derivatives showed an excellent antifungal activity against a clinical strain of Candida albicans and an interesting antitubercular activity against Mycobacterium tuberculosis H(37)Rv reference strain.

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