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. 2008 Apr 1;24(7):3417-21.
doi: 10.1021/la701688t. Epub 2008 Mar 7.

Hollow silica nanocontainers as drug delivery vehicles

Jaemoon Yang  1 , Jaewon Lee, Jinyoung Kang, Kwangyeol Lee, Jin-Suck Suh, Ho-Geun Yoon, Yong-Min Huh, Seungjoo Haam
Affiliations

Hollow silica nanocontainers as drug delivery vehicles

Jaemoon Yang et al. Langmuir. .

Abstract

Novel hollow silica nanoparticles (HSNPs) for drug delivery vehicles were synthesized using silica-coated magnetic assemblies, which are composed of a number of Fe(3)O(4) nanocrystals, as templates. The core cavity was obtained by removal of Fe(3)O(4) phase with hydrochloric acid and subsequent calcination at a high temperature. HSNPs were modified by amine in order to introduce positive surface charge and further PEGylated for increased solubility in aqueous medium. Doxorubicin as a model drug was loaded into the HSNPs, and notable sustained drug release from HSNPs was demonstrated.

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