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Review
. 2008 Mar;7(2):167-72.
doi: 10.1517/14740338.7.2.167.

The safety of diclofenac for the management and treatment of actinic keratoses

Fariba Iraji  1 , Amir Hossein Siadat, Ali Asilian, Shahla Enshaieh, Zabiholah Shahmoradi
Affiliations
Review

The safety of diclofenac for the management and treatment of actinic keratoses

Fariba Iraji et al. Expert Opin Drug Saf. 2008 Mar.

Abstract

Background: Actinic keratoses (AKs), defined as carcinoma in situ of squamous carcinoma, is usually induced by excessive sun exposure. The efficacy of 3% diclofenac in 2.5% hyaluronic acid gel for treatment of AKs has been documented in a few studies.

Objective: Is diclofenac safe and effective for the management and treatment of AKs?

Method: All the papers that were cited in Medline and ISI Web of Science are included in this study.

Results/conclusion: The use of diclofenac is associated with a few side effects, which include pruritus, rashes, dry skin, and scaling. These side effects are usually minimal and tolerable; therefore, this topical medication is suggested as the first line of treatment for AKs.

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