Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 May 22;60(8):915-28.
doi: 10.1016/j.addr.2007.05.017. Epub 2008 Feb 7.

Nanotechnology in vaccine delivery

Laura J Peek  1 , C Russell Middaugh, Cory Berkland
Affiliations
Review

Nanotechnology in vaccine delivery

Laura J Peek et al. Adv Drug Deliv Rev. .

Abstract

With very few adjuvants currently being used in marketed human vaccines, a critical need exists for novel immunopotentiators and delivery vehicles capable of eliciting humoral, cellular and mucosal immunity. Such crucial vaccine components could facilitate the development of novel vaccines for viral and parasitic infections, such as hepatitis, HIV, malaria, cancer, etc. In this review, we discuss clinical trial results for various vaccine adjuvants and delivery vehicles being developed that are approximately nanoscale (<1000 nm) in size. Humoral immune responses have been observed for most adjuvants and delivery platforms while only viral vectors, ISCOMs and Montanide ISA 51 and 720 have shown cytotoxic T cell responses in the clinic. MF59 and MPL have elicited Th1 responses, and virus-like particles, non-degradable nanoparticles and liposomes have also generated cellular immunity. Such vaccine components have also been evaluated for alternative routes of administration with clinical successes reported for intranasal delivery of viral vectors and proteosomes and oral delivery of a VLP vaccine.

PubMed Disclaimer

References

    1. Plotkin S.L., Plotkin S.A. A short history of vaccination. In: Plotkin S.A., Orenstein W.A., editors. Vaccines. WB Saunders Company; Philadelphia: 2004. pp. 1–15.
    1. Fenner F., Henderson D.A., Arita I., Jezek Z., Ladnyi I.D. World Health Organization; Geneva: 1988. Smallpox and Its Eradication.
    1. Smith J., Leke R., Adams A., Tangermann R.H. Certification of polio eradication: process and lessons learned. Bull. World Health Organ. 2004;82:24–30. - PMC - PubMed
    1. National Institute of Allergy and Infectious Diseases, Understanding vaccines: what they are and how they work. http://www.niaid.nih.gov/publications/vaccine/pdf/undvacc.pdf.
    1. National Center for Infectious Diseases . 2005. Disease Listing, Meningococcal Disease, General Info. http://www.cdc.gov/ncidod/dbmd/diseaseinfo/meningococcal_g.htm.