doi: 10.1126/science.183266.
Cytokine inhibition of DNA synthesis: effect on cyclic adenosine monophosphate in lymphocytes
- PMID: 183266
- DOI: 10.1126/science.183266
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Cytokine inhibition of DNA synthesis: effect on cyclic adenosine monophosphate in lymphocytes
Science.
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Abstract
A greater than twofold increase in intracellular adenosine 3',5'-monophosphate (cyclic AMP) inhibited DNA synthesis, in stimulated rat lymphocytes. A two- to fourfold rise of intracellular cyclic AMP, starting at 16 hours, was produced by purified inhibitor od DNA synthesis added to such cells either at 0 or 16 hours, in close association with the initiation of DNA synthesis.
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