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. 2008 Mar 21;6(6):1108-13.
doi: 10.1039/b800857b. Epub 2008 Feb 12.

N-Heterocyclic carbene catalysed beta-lactam synthesis

Nicolas Duguet  1 , Craig D Campbell, Alexandra M Z Slawin, Andrew D Smith
Affiliations

N-Heterocyclic carbene catalysed beta-lactam synthesis

Nicolas Duguet et al. Org Biomol Chem. .

Abstract

N-Heterocyclic carbenes promote the formal [2+2] cycloaddition of ketenes with N-tosyl imines to give the corresponding beta-lactams in good to excellent isolated yields; chiral NHCs give beta-lactams in high e.e. after crystallisation.

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