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Review
. 2008 Mar;22(1):85-100.
doi: 10.1016/j.berh.2007.12.012.

Osteogenesis imperfecta

Francis H Glorieux  1
Affiliations
Review

Osteogenesis imperfecta

Francis H Glorieux. Best Pract Res Clin Rheumatol. 2008 Mar.

Abstract

Osteogenesis Imperfecta is a heritable disorder characterized by bone fragility and low bone mass, with a wide spectrum of clinical expression. This review gives an update on its classification, the recent developments in the understanding of its pathophysiological mechanisms, and the current status of bisphosphonate therapy. Other therapeutic approaches and future directions of research are briefly discussed.

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