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. 2008 Jun;61(2):227-31.
doi: 10.1016/j.diagmicrobio.2008.01.019. Epub 2008 Mar 7.

In vitro activity of daptomycin against methicillin- and multi-resistant Staphylococcus haemolyticus invasive isolates carrying different mec complexes

Floriana Campanile  1 , Dafne Bongiorno, Sonia Borbone, Marco Falcone, Maddalena Giannella, Mario Venditti, Stefania Stefani
Affiliations

In vitro activity of daptomycin against methicillin- and multi-resistant Staphylococcus haemolyticus invasive isolates carrying different mec complexes

Floriana Campanile et al. Diagn Microbiol Infect Dis. 2008 Jun.

Abstract

Fifty methicillin and multi-resistant Staphylococcus haemolyticus (MRSH) strains, were tested against daptomycin and comparators. Daptomycin showed an overall MIC(90) value of 1 mg/L, similar to that of quinopristin/dalfopristin and lower than the values for vancomycin (2 mg/L), linezolid (2 mg/L) and teicoplanin (32 mg/L). Eighteen strains showed heteroresistant subpopulations with teicoplanin, whereas two strains were also heteroresistant to vancomycin and these sub-populations retained susceptibility to daptomycin. Our results show the good in vitro activity of daptomycin in MRSH strains possessing a multi-resistant phenotype. Clinical data on daptomycin efficacy are necessary to confirm our in vitro findings.

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