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. 2008 Mar 7;132(5):729-30.
doi: 10.1016/j.cell.2008.02.017.

Wnt signaling in the niche

Toshio Suda  1 , Fumio Arai
Affiliations
Free article

Wnt signaling in the niche

Toshio Suda et al. Cell. .
Free article

Abstract

There is much interest in understanding the signals in the bone marrow niche that keep hematopoietic stem cells (HSCs) in a quiescent state. In the current issue of Cell Stem Cell, Fleming et al. (2008) report that blocking Wnt signaling in the niche increases the number of proliferating HSCs and reduces their ability to reconstitute the hematopoietic system of irradiated recipient mice. These findings show that Wnt/beta-catenin activity is crucial for the maintenance of HSC quiescence in the bone marrow niche.

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