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. 2008 Jun;29(16):2548-55.
doi: 10.1016/j.biomaterials.2007.12.036. Epub 2008 Mar 10.

Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection

Jaemoon Yang  1 , Eun-Kyung Lim, Hong Jae Lee, Joseph Park, Sang Cheon Lee, Kwangyeol Lee, Ho-Geun Yoon, Jin-Suck Suh, Yong-Min Huh, Seungjoo Haam
Affiliations

Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection

Jaemoon Yang et al. Biomaterials. 2008 Jun.

Abstract

Cetuximab conjugated fluorescent magnetic nanohybrids (CET-FMNHs) were synthesized for detection of human epithelial cancer via magnetic resonance (MR) and optical imaging. Spherical FMNHs consist of MnFe(2)O(4) magnetic nanocrystals encapsulated in pyrene-labeled PCL-b-PMAA as a surfactant prepared by a nano-emulsion method. FMNHs demonstrated excellent colloidal stability and biocompatibility for biomedical application. Antibody conjugated fluorescent magnetic nanohybrids (CET-FMNHs) served as effective agents for both magnetic resonance (MR) and fluorescence optical imaging of cancer cell lines.

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