The ups and downs of hippocampal metabotropic glutamate receptors: ramifications for epileptogenesis and cognitive impairment following status epilepticus

Comment

Lisa R Merlin. Epilepsy Curr. 2008 Mar-Apr.

. 2008 Mar-Apr;8(2):43-5.

doi: 10.1111/j.1535-7511.2008.00232.x.

No abstract available

Comment on

Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy.
Pitsch J, Schoch S, Gueler N, Flor PJ, van der Putten H, Becker AJ. Pitsch J, et al. Neurobiol Dis. 2007 Jun;26(3):623-33. doi: 10.1016/j.nbd.2007.03.003. Epub 2007 Mar 16. Neurobiol Dis. 2007. PMID: 17446080
Loss of metabotropic glutamate receptor-dependent long-term depression via downregulation of mGluR5 after status epilepticus.
Kirschstein T, Bauer M, Müller L, Rüschenschmidt C, Reitze M, Becker AJ, Schoch S, Beck H. Kirschstein T, et al. J Neurosci. 2007 Jul 18;27(29):7696-704. doi: 10.1523/JNEUROSCI.4572-06.2007. J Neurosci. 2007. PMID: 17634364 Free PMC article.

1. Turski L, Ikonomidou C, Turski WA, Bortolotto ZA, Cavalheiro EA. Review: cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: a novel experimental model of intractable epilepsy. Synapse. 1989;3(2):154–171. - PubMed
1. Löscher W. Animal models of epilepsy for the development of antiepileptogenic and disease-modifying drugs. A comparison of the pharmacology of kindling and post-status epilepticus models of temporal lobe epilepsy. Epilepsy Res. 2002;50(1-2):105–123. - PubMed
1. Chen J, Larionov S, Pitsch J, Hoerold N, Ullmann C, Elger CE, Schramm J, Becker AJ. Expression analysis of metabotropic glutamate receptors I and III in mouse strains with different susceptibility to experimental temporal lobe epilepsy. Neurosci Lett. 2005;375:192–197. - PubMed
1. Akbar MT, Rattray M, Powell JF, Meldrum BS. Altered expression of group I metabotropic glutamate receptors in the hippocampus of amygdala-kindled rats. Mol Brain Res. 1996;43:105–116. - PubMed
1. Braunewell KH, Manahan-Vaughan D. Long-term depression: a cellular basis for learning? Rev Neurosci. 2001;12:121–140. - PubMed