Antiepileptic drug transport--of mice and men

Comment

Graeme J Sills. Epilepsy Curr. 2008 Mar-Apr.

. 2008 Mar-Apr;8(2):48-50.

doi: 10.1111/j.1535-7511.2008.00234.x.

No abstract available

Comment on

Valproic acid is not a substrate for P-glycoprotein or multidrug resistance proteins 1 and 2 in a number of in vitro and in vivo transport assays.
Baltes S, Fedrowitz M, Tortós CL, Potschka H, Löscher W. Baltes S, et al. J Pharmacol Exp Ther. 2007 Jan;320(1):331-43. doi: 10.1124/jpet.106.102491. Epub 2006 Oct 16. J Pharmacol Exp Ther. 2007. PMID: 17043155
Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein.
Baltes S, Gastens AM, Fedrowitz M, Potschka H, Kaever V, Löscher W. Baltes S, et al. Neuropharmacology. 2007 Feb;52(2):333-46. doi: 10.1016/j.neuropharm.2006.07.038. Epub 2006 Oct 10. Neuropharmacology. 2007. PMID: 17045309

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